new thread
Journal Invest Dermatol 2001 Sep;117(3):605-11
Cyclosporin A promotes hair epithelial cell proliferation and modulates protein kinase c expression and translocation in hair epithelial cells.
Takahashi T, Kamimura A.
Tsukuba Research Laboratories, Kyowa Hakko Kogyo Co., Tsukuba, Ibaraki, Japan.
Cyclosporin A is an immunosuppressive agent known to cause hirsutism. The mechanisms of action that cause hirsutism have not been fully elucidated, however. We have previously reported that several selective protein kinase C inhibitors promote the growth of murine hair epithelial cells and stimulate anagen induction. In this paper, we report on an investigation of the mechanisms of action of hair-growing activity possessed by cyclosporin A from the viewpoint of whether it promotes hair epithelial cell growth or whether it modulates the expression or translocation of protein kinase C isozymes in hair epithelial cells.
Our results indicate that cyclosporin A (over a wide dosage range of 1-1000 ng per ml) stimulates cultured murine hair epithelial cell growth to about 150%-160% relative to controls. We also observed growth-promoting effects on murine epidermal